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The Tumor Microenvironment

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The Tumor Microenvironment by Rebecca G. Bagley Book Summary:

The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed “immune surveillance” in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.

The Tumor

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The Tumor by John Grisham,Focused Ultrasound Foundation Book Summary:

John Grisham says THE TUMOR is the most important book he has ever written. In this short book, he provides readers with a fictional account of how a real, new medical technology could revolutionize the future of medicine by curing with sound. THE TUMOR follows the present day experience of the fictional patient Paul, an otherwise healthy 35-year-old father who is diagnosed with a malignant brain tumor. Grisham takes readers through a detailed account of Paul’s treatment and his family’s experience that doesn’t end as we would hope. Grisham then explores an alternate future, where Paul is diagnosed with the same brain tumor at the same age, but in the year 2025, when a treatment called focused ultrasound is able to extend his life expectancy. Focused ultrasound has the potential to treat not just brain tumors, but many other disorders, including Parkinson’s, Alzheimer’s, hypertension, and prostate, breast and pancreatic cancer. For more information or to order a free hardcopy of the book, please visit The Focused Ultrasound Foundation’s website www.fusfoundation.org. Here you will find a video of Grisham on the TEDx stage with the Foundation’s chairman and a Parkinson’s patient who brings the audience to its feet sharing her incredible story of a focused ultrasound “miracle.” Readers will get a taste of the narrative they expect from Grisham, but this short book will also educate and inspire people to be hopeful about the future of medical innovation.

Innate and Adaptive Immunity in the Tumor Microenvironment

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Innate and Adaptive Immunity in the Tumor Microenvironment by Eitan Yefenof Book Summary:

Traditionally, the interplay between cancer cells and host immunity has been studied systemically. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. This volume compiles reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease.

Regulation of Gene Expression in the Tumor Environment

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Regulation of Gene Expression in the Tumor Environment by Menashe Bar-Eli Book Summary:

It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.

The Tumor Immunoenvironment

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The Tumor Immunoenvironment by Michael R Shurin,Viktor Umansky,Anatoli Malyguine Book Summary:

Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.

Humor After the Tumor

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Humor After the Tumor by Patty Gelman Book Summary:

Breast cancer survivor Patty Gelman recounts her journey through "Cancer World" in a series of anecdotes, chronicling her year-long struggle with the disease in an upbeat, colloquial, and often candidly funny way. Typical of her unyieldingly positive attitude is the way that Gelman breaks the news to her mother, also a cancer survivor: "'Well, it's my turn now!'" Instead of keeping a journal during her treatment, Gelman preferred to share her experiences online, a choice she found surprisingly therapeutic. What started as periodic e-mails to family and friends soon developed into a book many cancer patients are turning to for hope. E-mails also served as an outlet and a built-in support group when her mother contracted lung cancer and passed on within the year. Gelman's story becomes larger than her disease, exploring the task of coping with the unexpected, and the value of family.

Shrinkage: Manhood, Marriage, and the Tumor That Tried to Kill Me

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Shrinkage: Manhood, Marriage, and the Tumor That Tried to Kill Me by Bryan Bishop Book Summary:

A New York Times bestseller! An Amazon Best Books of 2014 selection "If you're reading this, it means I'm already dead. Just kidding." In 2009, at thirty years old, Bryan Bishop's life was right on track. Known to millions as "Bald Bryan," the sidekick and soundman on the record-setting podcast, The Adam Carolla Show, his radio career was taking off. He was newly engaged. Then, he and his fiancée Christie were delivered a crushing blow when he was diagnosed with a brain stem glioma—an inoperable brain tumor. Suddenly Bryan's promising future was transformed into a grueling schedule of radiation and chemotherapy while facing his mortality. In this poignant narrative that is alternately heartbreaking and hysterical, Bishop shares the surreal experiences of writing his will with the bravado of a pulp novelist, taking chemo in a strip club, and (technically) the closest he ever got to achieving his lifelong dream of a threesome—when a physical therapist had to show his wife how to bathe him in the shower during his weakened state. Whether recounting his search for the most aggressive form of treatment, how radiation treatment jeopardized his ability to (literally) walk down the aisle or even smile for his wedding photos, or recalling the time his wife inadvertently drugged him in a pool in Maui, Bishop's inimitable voice radiates through his story. As the author celebrates how treatment shrunk his tumor and gave him a new lease on life, Shrinkage reveals the resilience of the human spirit—and the power of laughter—during even the darkest times.

Tumor Microenvironment

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Tumor Microenvironment by Alexander Birbrair Book Summary:

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The Role of Chemoattractants in the Tumor Microenvironment

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The Role of Chemoattractants in the Tumor Microenvironment by Giovanni Bernardini,Brian A. Zabel Book Summary:

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Tumors and Tumor-like Conditions of the Lung and Pleura E-Book

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Tumors and Tumor-like Conditions of the Lung and Pleura E-Book by Cesar A. Moran,Saul Suster Book Summary:

Tumors and Tumor-like Conditions of the Lung and Pleura is a superb visual resource that brings the state-of-the-art in thoracic diagnosis straight to the lab bench. Cesar A. Moran and Saul Suster are internationally recognized experts in pulmonary pathology who present a coherent and consistent approach to interpretation and diagnosis. Through more than 900 stunning photographs and a consistent, user-friendly format, this resource provides quality guidance on the diagnostic problems you face in everyday practice. You’ll get a host of innovative, practice-oriented features unavailable in any other text that streamline and facilitate diagnostic decision-making. Written by practitioners for practitioners, this visual resource is designed for quick and easy use. You can’t afford to be without it. Features over 900 high-quality full-color illustrations so you can recognize and diagnose any tissue sample under the microscope. Presents immunohistochemical and genetic features wherever relevant for comprehensive information on all of the investigative contexts important to formulating an accurate diagnosis. Includes summary tables throughout the text to simplify and clarify complex discussions and enable "at a glance" comparisons between entities. Provides practical advice from experts on pitfalls in differential diagnosis to help you avoid diagnostic errors.

Mental Leaps

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Mental Leaps by Keith J. Holyoak,Keith James Holyoak,Paul Thagard Book Summary:

Analogy - recalling familiar past situations to deal with novel ones - can provide invaluable creative insights, but it can also lead to dangerous errors. In Mental Leaps, two leading cognitive scientists show how analogy works and how it can be used most effectively. Keith Holyoak and Paul Thagard provide a unified, comprehensive account of the diverse operations and applications of analogy, including problem solving, decision making, explanation, and communication. They present their own theory of analogy, considering its implications for cognitive science in general, and survey examples from many other domains.

Tumors of the Central Nervous System, Volume 10

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Tumors of the Central Nervous System, Volume 10 by M.A. Hayat Book Summary:

Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research—the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared objectivity among academics engaged in one of the most important medical endeavors of our era. It brings together the very latest work by oncologists, neurosurgeons, physicians, research scientists, and pathologists, providing the medical community with a wealth of data and results that, taken together, will advance the cause of cancer research. The volume synthesizes work on diagnosis, drug development, and therapeutic approaches that are typically scattered in a variety of journals and books. It features promising recent work in applying molecular genetics to clinical practice and evidence-based therapy, covering molecular profiling of tumors as well as a number of surgical treatments such as resection and radiosurgery. Together with its counterpart publications, it represents a much-needed central resource that will inform and guide future research efforts.

Cancer Drug Delivery Systems Based on the Tumor Microenvironment

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Cancer Drug Delivery Systems Based on the Tumor Microenvironment by Yasuhiro Matsumura,David Tarin Book Summary:

This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.

Bone and Soft Tissue Tumors

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Bone and Soft Tissue Tumors by Mario Campanacci Book Summary:

A systematic treatise of tumors and tumor-like lesions occurring in bone and soft tissues. The introductory chapter presents the terminology, the basic principles for classification and diagnosis, the general principles of imaging, biopsy and histology, the staging system and evaluation of the surgical margins, the general principles of curettage, local adjuvants, en bloc resection and reconstruction, chemotherapy and radiotherapy. Each pathologic entity is described according to its epidemiology, localization, symptoms, imaging, gross pathology, histopathology, histogenesis and pathogenesis, differential diagnosis, course and stage, treatment and prognosis.

Influence of the Host on Tumor Development

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Influence of the Host on Tumor Development by Ronald B. Herberman Book Summary:

It is widely recognized that the host response to tumor munotherapy of experimental metastases in animal systems progression is an important determinant in cancer growth which are beginning to be developed for ultimate clinical and progression. Indeed, as indicated in Volume I of this trials of human cancer metastasis. series, the process of cancer growth and progression, leading This volume explores a variety of host properties that to tumor invasion and metastasis, is dependent upon the influence tumor development including dormancy, regress complex, dynamic interactions between the properties of the ion, and recurrence. In addition, current knowledge of the tumor as well as the properties of the host. While Volume III response of the central nervous system to cancer, cardiac of this series reviews in great detail the influence of tumor and pulmonary complications, dermatologic effects and development on the host, this volume emphasizes the in hematologic complications of malignancies is presented. fluence of the host on tumor development. These host re The endocrine and metabolic function of cancer patients, as sponses include host anti-tumor immune reactivity, tumor well as the production of hormones by tumors is also review dormancy, cachexia, multiple endocrine and paraneoplastic ed.

Brain Tumors E-Book

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Brain Tumors E-Book by Andrew H. Kaye,Edward R. Laws Jr Book Summary:

Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.

Influence of Tumor Development on the Host

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Influence of Tumor Development on the Host by L.A. Liotta Book Summary:

Recent experimental evidence has made it increasingly clear In particular, this volume reviews the discrete steps involved that the properties of invasive, malignant cells during tumor in metastatic invasion: the interaction of invasive tumor cells development substantially impact on the host. This is under with extracellular matrices, the basement membrane, attach scored by a variety of biochemical properties of tumor cells ment to extracellular matrices, local proteolytic degradation during their differentiation and metastatic dissemination. of matrices, and the locomotion of invasive tumor cells These properties can be analyzed at different stages of tumor through such areas of localized degradation. The critical growth and progression and this volume explores the role of the cell surface in secondary tumor formation is characteristics of primary tumors as well as the shared reviewed as are important advances in the molecular biology characteristics of both primary and secondary tumors. of metastasis initiation and maintenance. Recent advances The primary tumor comes into existence following in the role of DNA methylation in the generation of tumor preneoplastic biochemical and cellular events that ultimate cell heterogeneity and tumor progression are also critically ly result in malignant transformation. Various aspects of summarized. Chapters in this volume also review molecular metabolism, predetermined by nutritional status, often play aspects of metastatic progression, and the use of the tech a basic role. Obesity, for example, is cancer-promoting. Cell nologies of DNA transfection and somatic cell fusion in the surface carbohydrates, cytoskeletal proteins, glycoproteins, exploration of molecular aspects of metastatic progression.

Tumors of the Esophagus and Stomach

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Tumors of the Esophagus and Stomach by Si-Chun Ming,Armed Forces Institute of Pathology (U.S.) Book Summary:

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Chroniques de Ford County

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Chroniques de Ford County by John GRISHAM Book Summary:

Un avocat frustré détourne des dommages-intérêts de ses clients ; un arnaqueur se prétend en partie amérindien pour ouvrir un casino ; un surveillant dans une maison de retraite manipule les patients et le personnel ; trois hommes partis en virée pour faire un don de sang s'arrêtent dans un club de strip-tease et finissent en prison ; la famille d'un homosexuel blanc atteint du sida demande à une vieille femme noire de le soigner jusqu'à sa mort... Dans un de ses livres les plus personnels, John Grisham nous emmène au coeur du comté du Mississippi où se déroulait déjà l'intrigue de son premier roman, Non coupable. Le sud des États-Unis et ses petites villes enclavées offrent, bien plus qu'un décor, un climat, un fi l conducteur et constituent presque un personnage à part entière. Tantôt captivantes, tantôt émouvantes, ces Chroniques de Ford County décrivent les destins ordinaires ou extraordinaires de personnages qui se révèlent étonnamment proches de nous : leurs sentiments et leurs faiblesses, brossés avec justesse et souvent beaucoup d'humour, sont universels. Au détour d'une histoire, au creux d'un portrait, on découvre, s'il en était encore besoin, le talent de conteur de John Grisham.