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Overspill by Ali Taylor Book Summary:
A poetic, explosive thriller about teenagers on a night out that ends in violence. Winner of Metamorphosis 2008. In Bromley every Friday night, same time and place, Potts, Baron and Finch get ready for their weekly dose of booze, birds and burgers. But their night out takes a dramatic and terrifying twist when an explosion rocks the town centre, and a suspicious population points the finger at them. ''"Overspill" is set in Bromley, but it could be set in any town anywhere in the UK. There are hundreds of Bromleys in Britaina These are the towns that millions of us grow up in.'' - "Ali Taylor" ''Ali Taylor''s slice of urban life is small but thrilling. It is driven by a pulsating rhythm, a sense of place, a menacing undercurrent of casual violence waiting to erupt, and a layered story that suggests the lads'' friendship was about to be blown apart by other factors as adolescence gives way to adulthood. The writing is gritty and sweaty, with a tom cat swagger and cut with half-rhymes and littered with assonance and alliteration... a tiny gem''- "Guardian" ''A dazzling display of dramatic virtuosity... darkly polished, thrillingly inventive... gleams with gutter poetry''- "Time Out""
The Diabetes Textbook by Joel Rodriguez-Saldana Book Summary:
Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.
Protein Structure and Modeling by Natalya Kurochkina Book Summary:
This book will consider principles of the organization of protein molecules, the relationships between primary, secondary, and tertiary structure, the determinants of protein conformation, and the applications of structure determination and structure modeling in biomedical research.
Mosquitoes by Lucy Kirkwood Book Summary:
Alice is a scientist. She lives in Geneva. As the Large Hadron particle collider starts up in 2008, she is on the brink of the most exciting work of her life, searching for the Higgs Boson. Jenny is her sister. She lives in Luton. She spends a lot of time googling. When tragedy throws them together, the collision threatens them all with chaos.
Development of Biopharmaceutical Drug-Device Products by Feroz Jameel,John W. Skoug,Robert R. Nesbitt Book Summary:
The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T-cell engager (BITES), Dual Variable Domain (DVD) antibodies, and fusion proteins that are currently being used as therapeutic agents for immunology, oncology and other disease conditions. Regulatory agencies have raised the bar for the development and manufacture of antibody-based products, expecting to see the use of Quality by Design (QbD) elements demonstrating an in-depth understanding of product and process based on sound science. Drug delivery systems have become an increasingly important part of the therapy and most biopharmaceuticals for self-administration are being marketed as combination products. A survey of the market indicates that there is a strong need for a new book that will provide “one stop shopping” for the latest information and knowledge of the scientific and engineering advances made over the last few years in the area of biopharmaceutical product development. The new book entitled Development of Biopharmaceutical Drug Device Products is a reference text for scientists and engineers in the biopharmaceutical industry, academia or regulatory agencies. With insightful chapters from experts in the field, this new book reviews first principles, covers recent technological advancements and provides case studies and regulatory strategies relating to the development and manufacture of antibody-based products. It covers topics such as the importance of early preformulation studies during drug discovery to influence molecular selection for development, formulation strategies for new modalities, and the analytical techniques used to characterize them. It also addresses important considerations for later stage development such as the development of robust formulations and processes, including process engineering and modeling of manufacturing unit operations, the design of analytical comparability studies, and characterization of primary containers (pre-filled syringes and vials).Finally, the latter half of the book reviews key considerations to ensure the development and approval of a patient-centered delivery system design. This involves the evolving regulatory framework with perspectives from both the US and EU industry experts, the role of international standards, design control/risk management, human factors and its importance in the product development and regulatory approval process, as well as review of the risk-based approach to bridging between devices used in clinical trials and the to-be-marketed device. Finally, case studies are provided throughout.The typical readership would have biology and/or engineering degrees and would include researchers, scientific leaders, industry specialists and technology developers working in the biopharmaceutical field.
Abiotic Stress Physiology of Horticultural Crops by N.K. Srinivasa Rao,K.S. Shivashankara,R.H. Laxman Book Summary:
This book brings together recent advances in the area of abiotic stress tolerance in various vegetables, fruit crops, plantation crops and tuber crops. The main challenges to improving the productivity of horticultural crops are the different types of abiotic stresses generally caused by climate change at the regional and global level. Heat, drought, cold and salinity are the major abiotic stresses that adversely affect growth and productivity and can trigger a series of morphological, physiological, biochemical and molecular changes in various horticultural crops. To date, there are no books covering horticultural crop-specific abiotic stress tolerance mechanisms and their management. Addressing that gap, the book is divided into 2 sections, the first of which highlights recent advances in the general aspects of abiotic stress tolerance like the role of hormones, reactive oxygen species, seed treatments, molecular mechanisms of heat tolerance and heavy metal toxicity, while the second focuses on the abiotic stress tolerance mechanisms of various vegetables, fruit crops, plantation crops and tuber crops. It includes comprehensive discussions of fruit crops like mango, grapes, banana, litchi and arid zone fruits; vegetables crops like tomato, capsicum, onion and tuber crops; and plantation crops like coconut, areca nut, oil palm and black pepper. Among the strategies for plant stress survival, examples of both avoidance and tolerance relevant to particular crops are examined in detail, supported by selected comprehensive case studies of progress. As such, the book offers a valuable resource suited for scientists and graduate students working in the fields of crop improvement, genetic engineering, and the abiotic stress tolerance of horticultural crops.
Handbook of Analytic Philosophy of Medicine by Kazem Sadegh-Zadeh Book Summary:
Medical practice is practiced morality, and clinical research belongs to normative ethics. The present book elucidates and advances this thesis by: 1. analyzing the structure of medical language, knowledge, and theories; 2. inquiring into the foundations of the clinical encounter; 3. introducing the logic and methodology of clinical decision-making, including artificial intelligence in medicine; 4. suggesting comprehensive theories of organism, life, and psyche; of health, illness, and disease; of etiology, diagnosis, prognosis, prevention, and therapy; and 5. investigating the moral and metaphysical issues central to medical practice and research. Many systems of (classical, modal, non-classical, probability, and fuzzy) logic are introduced and applied. Fuzzy medical deontics, fuzzy medical ontology, fuzzy medical concept formation, fuzzy medical decision-making and biomedicine and many other techniques of fuzzification in medicine are introduced for the first time.
Climate Change Modelling, Planning and Policy for Agriculture by Anil Kumar Singh,Jagdish Chander Dagar,Ayyanadar Arunachalam,Gopichandran R,Kirit Nanubhai Shelat Book Summary:
It is well known that the impacts of climate change are tangible and hence there can be no debate about the need for appropriate adaptation measures, on a priority basis. However, it is equally important to recognize the fact that adaptation measures actually represent a dynamic synthesis of interventions pertaining to multiple systems. These are particularly of water, soil characteristics, genotypic and phenotypic variations and their expressions, age-correlated biochemical changes aligned with planting schedules and favorable weather/climate conditions. Nutrients, occurrence and distribution of associated vegetation including crop mixes also influence productivity. The overarching aspect of farming practice wields significant influence on the outcome and hence it is important to be clear about the particular focus of the investigations being carried out and reported in a suitable manner. It is essential to recognize that scientific research in agriculture in India has always produced valuable results of direct relevance to her people. Importantly, preparedness to tackle disasters due to inclement weather system has prominently featured on the agenda. The recent focus on climate change and impacts has provided the necessary impetus to reorganize the framework of investigation to capture the specifics of such impacts. In this context, the importance of micro climate variations too viz-a-viz the larger scales of impacts cannot be overemphasized. It will be useful to also help characterize natural variations versus artificially induced variations, helping us understand the complexities of individual and synergistic impacts too. Obviously, the limits and limitations of models could determine the spread and depth of the outcomes of investigations. Empirical evidences to reinforce assumptions have to also be documented with utmost care; guided by an understanding of the limits of tolerance, limiting factors, and the precautionary principle especially in the public policy interface. The present volume therefore, showcases these strands with the fond hope that they will stimulate further thinking and enable appropriate action.
Public Transport Planning and Management in Developing Countries by Ashish Verma,T.V. Ramanayya Book Summary:
Developing Countries Have Different Transportation Issues and Requirements Than Developed Countries An efficient transportation system is critical for a country’s development. Yet cities in developing countries are typically characterized by high-density urban areas and poor public transport, as well as lack of proper roads, parking facilities, road user discipline, and control of land use, resulting in pollution, congestion, accidents, and a host of other transportation problems. Public Transport Planning and Management in Developing Countries examines the status of urban transport in India and other developing countries. It explains the principles of public transport planning and management that are relevant and suitable for developing countries, addresses current transportation system inefficiencies, explores the relationship between mobility and accessibility, and analyzes the results for future use. Considers Socioeconomic and Demographic Characteristics It’s projected that by 2030, developing nations will have more vehicles than developed nations, and automated guided transit (AGT) and other transport systems will soon be available in India. This text compares five cities using specific indicators—urbanization, population growth, vehicle ownership, and usage. It determines demographic and economic changes in India, and examines how these changes have impacted transportation demand and supply, transport policy and regulations, and aspects of economics and finance related to public transport. The authors emphasize preserving and improving existing modes, efficient use of the public transport management infrastructure, implementing proper planning measures, and encouraging a shift towards sustainable modes. They also discuss sustainability in terms of environment, energy, economic, and land use perspectives and consider the trends of motorization, vehicle growth, modal share, effects on mobility and environment, and transport energy consumption and emissions. Public Transport Planning and Management in Developing Countries addresses the growing resource needs and economics of public transport in developing countries, explains various aspects of public transport planning and management, and provides readers with a basic understanding of both urban and rural public transport planning and management in developing countries.
Uncle Vanya by Anton Chekhov - Delphi Classics (Illustrated) by Anton Chekhov Book Summary:
This eBook features the unabridged text of ‘Uncle Vanya’ from the bestselling edition of ‘The Complete Works of Anton Chekhov’. Having established their name as the leading publisher of classic literature and art, Delphi Classics produce publications that are individually crafted with superior formatting, while introducing many rare texts for the first time in digital print. The Delphi Classics edition of Chekhov includes original annotations and illustrations relating to the life and works of the author, as well as individual tables of contents, allowing you to navigate eBooks quickly and easily. eBook features: * The complete unabridged text of ‘Uncle Vanya’ * Beautifully illustrated with images related to Chekhov’s works * Individual contents table, allowing easy navigation around the eBook * Excellent formatting of the textPlease visit www.delphiclassics.com to learn more about our wide range of titles
Compact Cities by Rod Burgess,Mike Jenks Book Summary:
This collection of edited papers forms part of the Compact City Series, creating a companion volume to The Compact City (1996) and Achieving Sustainable Urban Form (2000) and extends the debate to developing countries. This book examines and evaluates the merits and defects of compact city approaches in the context of developing countries in Africa, Asia and Latin America. Issues of theory, policy and practice relating to sustainability of urban form are examined by a wide range of international academics and practitioners.
Integrated Pest Management of Tropical Vegetable Crops by Rangaswamy Muniappan,E. A. Heinrichs Book Summary:
It is an edited book with chapters written by multi-disciplinary specialists in their specific subject areas. It covers development of IPM components and packaging them for individual vegetable crops specifically targeted to tropical countries. Scientific background for IPM components or tactics will be included. There will be case studies of IPM packages developed and implemented in different countries. The concept of IPM has been in existence for the past six decades; however, a practical holistic program has not been developed and implemented for vegetable crops, in the developing countries. Currently the IPM adoption rate in the tropics is minimal and there is a need for implementation of IPM technologies that are environmentally safe, economical, and socially acceptable. We believe that adoption and implementation of IPM provided in this book will lead to significant reduction in crop losses and mitigate adverse impacts of pesticide use in the tropics. This book is an outcome 20 years of research, development and implementation of the IPM CRSP, a project supported by USAID and administered by Virginia Tech in several developing countries along the tropical belt in Africa, Asia, Latin America and the Caribbean.
Organic Synthesis with Carbohydrates by Geert-Jan Boons,Karl J. Hale Book Summary:
Carbohydrates offer a ready source of enantiomerically pure starting materials. They have been used for the imaginative synthesis of a wide range of compounds, and have been found to be effective chiral auxiliaries which enable the introduction of a range of functionalities in a highly enantioselective manner. In a subject dominated by volumes at research and professional level, this book provides a broad understanding of the use of carbohydrates in organic synthesis, at postgraduate student level. Emphasis is placed on retrosynthetic analysis, with discussion of why a particular synthetic route has been chosen, and mechanistic explanations are provided for key and novel reactions. Wherever possible, the authors highlight points of general significance to organic synthesis. Selected experimental conditions and reaction details are incorporated to ensure that information can be utilised in research. The book is extensively referenced and so provides a convenient point of entry to the primary literature.
Polymers for Biomedicine by Carmen Scholz Book Summary:
-This book highlights dynamic developments in polymer synthesis, focusing on synthetic techniques that yield new biomedically relevant polymers, macromolecular super-structures, and biopolymers for surface modification. An added emphasis deals with characterizing these polymers through structure verification---
Cyclin Dependent Kinase 5 (Cdk5) by Nancy Y. Ip,Li-Huei Tsai Book Summary:
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Handbook of Transportation Engineering by Myer Kutz Book Summary:
This is a comprehensive, problem-solving engineering guide on the strategic planning, development, and maintenance of public and private transportation systems. Covering all modes of transportation on land, air, and water, the Handbook shows how to solve specific problems, such as facility improvement, cost reduction, or operations optimization at local, regional, national, and international levels. * Extensive sections on road construction and maintenance, bridge construction and repair, and mass transit systems * Examines airline traffic control systems, airline schedule planning, and airline ground operation * Covers marine, rail, and freight transportation
Advances in Computational and Bio-Engineering by S. Jyothi,D. M. Mamatha,Suresh Chandra Satapathy,K. Srujan Raju,Margarita N. Favorskaya Book Summary:
This book gathers state-of-the-art research in computational engineering and bioengineering to facilitate knowledge exchange between various scientific communities. Computational engineering (CE) is a relatively new discipline that addresses the development and application of computational models and simulations often coupled with high-performance computing to solve complex physical problems arising in engineering analysis and design in the context of natural phenomena. Bioengineering (BE) is an important aspect of computational biology, which aims to develop and use efficient algorithms, data structures, and visualization and communication tools to model biological systems. Today, engineering approaches are essential for biologists, enabling them to analyse complex physiological processes, as well as for the pharmaceutical industry to support drug discovery and development programmes.
Concepts and Methods of 2D Infrared Spectroscopy by Peter Hamm,Martin Zanni Book Summary:
2D infrared (IR) spectroscopy is a cutting-edge technique, with applications in subjects as diverse as the energy sciences, biophysics and physical chemistry. This book introduces the essential concepts of 2D IR spectroscopy step-by-step to build an intuitive and in-depth understanding of the method. This unique book introduces the mathematical formalism in a simple manner, examines the design considerations for implementing the methods in the laboratory, and contains working computer code to simulate 2D IR spectra and exercises to illustrate involved concepts. Readers will learn how to accurately interpret 2D IR spectra, design their own spectrometer and invent their own pulse sequences. It is an excellent starting point for graduate students and researchers new to this exciting field. Computer codes and answers to the exercises can be downloaded from the authors' website, available at www.cambridge.org/9781107000056.
More Golden Rules of Acting by Andy Nyman Book Summary:
Andy Nyman's first book, The Golden Rules of Acting, has become a bestseller in the acting world. Now he returns to bring you more priceless nuggets gleaned from more than thirty years in the acting business. This book will help you to... Learn to love auditions and self-tapes (yes, really!) Look after your mental health Deal with success and failure Burst a few bubbles that need bursting Written with the same candid wit as his first book, this is every actor's new best friend - in handy paperback form. 'With great humour, wisdom and panache, Andy Nyman presents tasty advice for any actor. He knows that the more rules and craft under your belt, the more daring and original you will be as an artist' Glenn Close 'As with the first volume, this book gets to the heart of what being a working actor is about. No faff, no mystery, just practicalities that are always worth being reminded of' Martin Freeman 'One man shouldn't be so wise and entertaining, but Andy Nyman somehow is. His latest Golden Rules are exactly that -- and wild fun, to boot. I recommend this book not just to actors, but to anyone who has ever seen an actor act. Nyman's insights apply to us all' J.J. Abrams
A Mathematical Approach to Protein Biophysics by L. Ridgway Scott,Ariel Fernández Book Summary:
This book explores quantitative aspects of protein biophysics and attempts to delineate certain rules of molecular behavior that make atomic scale objects behave in a digital way. This book will help readers to understand how certain biological systems involving proteins function as digital information systems despite the fact that underlying processes are analog in nature. The in-depth explanation of proteins from a quantitative point of view and the variety of level of exercises (including physical experiments) at the end of each chapter will appeal to graduate and senior undergraduate students in mathematics, computer science, mechanical engineering, and physics, wanting to learn about the biophysics of proteins. L. Ridgway Scott has been Professor of Computer Science and of Mathematics at the University of Chicago since 1998, and the Louis Block Professor since 2001. He obtained a B.S. degree (Magna Cum Laude) from Tulane University in 1969 and a PhD degree in Mathematics from the Massachusetts Institute of Technology in 1973. Professor Scott has published over 130 papers and three books, extending over biophysics, parallel computing and fundamental computing aspects of structural mechanics, fluid dynamics, nuclear engineering, and computational chemistry. Ariel Fernández (born Ariel Fernández Stigliano) is an Argentinian-American physical chemist and mathematician. He obtained his Ph. D. degree in Chemical Physics from Yale University and held the Karl F. Hasselmann Endowed Chair Professorship in Bioengineering at Rice University. He is currently involved in research and entrepreneurial activities at various consultancy firms. Ariel Fernández authored three books on translational medicine and biophysics, and published 360 papers in professional journals. He holds two patents in the field of biotechnology.
Biotechnologies of Crop Improvement, Volume 3 by Satbir Singh Gosal,Shabir Hussain Wani Book Summary:
During the past 15 years, cellular and molecular approaches have emerged as valuable adjuncts to supplement and complement conventional breeding methods for a wide variety of crop plants. Biotechnology increasingly plays a role in the creation, conservation, characterization and utilization of genetic variability for germplasm enhancement. For instance, anther/microspore culture, somaclonal variation, embryo culture and somatic hybridization are being exploited for obtaining incremental improvement in the existing cultivars. In addition, genes that confer insect- and disease-resistance, abiotic stress tolerance, herbicide tolerance and quality traits have been isolated and re-introduced into otherwise sensitive or susceptible species by a variety of transgenic techniques. Together these transformative methodologies grant access to a greater repertoire of genetic diversity as the gene(s) may come from viruses, bacteria, fungi, insects, animals, human beings, unrelated plants or even be artificially derived. Remarkable achievements have been made in the production, characterization, field evaluation and commercialization of transgenic crop varieties worldwide. Likewise, significant advances have been made towards increasing crop yields, improving nutritional quality, enabling crops to be raised under adverse conditions and developing resistance to pests and diseases for sustaining global food and nutritional security. The overarching purpose of this 3-volume work is to summarize the history of crop improvement from a technological perspective but to do so with a forward outlook on further advancement and adaptability to a changing world. Our carefully chosen “case studies of important plant crops” intend to serve a diverse spectrum of audience looking for the right tools to tackle complicated local and global issues.
Literature on Adam and Eve by Gary Alan Anderson,Michael Edward Stone,Johannes Tromp Book Summary:
This volume is a collection of articles by some of the foremost scholars in the field, dealing with the rich variety of Adam and Eve-traditions, from "The Life of Adam and Eve" onwards to late medieval writings in Armenian.
Biology of Rhodococcus by Héctor M. Alvarez Book Summary:
Rhodococcus, a metabolically versatile actinobacteria which is frequently found in the environment, has gained increasing interest due to its potential biotechnological applications. This Microbiology Monographs volume provides a thorough review of the various aspects of the biochemistry, physiology and genetics of the Genus Rhodococcus. Following an overview of its taxonomy, chapters cover the structural aspects of rhodococcal cellular envelope, genomes and plasmids, metabolic and catabolic pathways, such as those of aromatic compounds, steroids and nitriles, and desulfurization pathways, as well as the adaption to organic solvents. Further reviews discuss applications of Rhodococcus in the bioremediation of contaminated environments, in triacylglycerol accumulation, and in phytopathogenic strategies, as well as the potential of biosurfactants. A final chapter describes the sole pathogenic Rhodococcus member, R. equi.
The Picornaviruses by Ellie Ehrenfeld,Esteban Domingo,Raymond P. Roos Book Summary:
A springboard for developing new approaches to understanding, preventing, and treating picornaviral diseases. • Examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research; encapsulates current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses; and, examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases. • Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth; and, illustrates how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. • Focuses on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.
Biology and Biotechnology of Actinobacteria by Joachim Wink,Fatemeh Mohammadipanah,Javad Hamedi Book Summary:
This book provides in-depth insights into the biology, taxonomy, genetics, physiology and biotechnological applications of Actinobacteria. It especially focuses on the latter, reviewing the wide variety of actinobacterial bioactive molecules and their benefits for diverse industrial applications such as agriculture, aquaculture, biofuel production and food technology. Actinobacteria are one of the most promising sources of small bioactive molecules and it is estimated that only a small percentage of actinobacterial bioactive chemicals have been discovered to date. Identifying new diverse gene clusters of biotechnological relevance in the genome of Actinobacteria will be crucial to developing advanced applications for pharmaceutical, industrial and agricultural purposes. The book offers a unique resource for all graduate students, researchers and practitioners in the fields of microbiology, microbial biotechnology, and the genetic engineering of Actinobacteria.